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Hilla University College Journal For Medical Science

Document Type

Original Study

Keywords

Sickle cell disease, Steady state, Vasoocclusive crisis, Inflammation

Abstract

Background: Sickle cell disease is a monogenetic disorder resulting in early mortality and widespread organ damage, including pulmonary, cardiac, and splenic dysfunction, as well as cerebral infarcts and avascular osteonecrosis. It results from a single point mutation causing the replacement of the amino acid glutamic acid by valine. Chronic hemolysis can affect sickled red cells, chronic inflammation, and oxidative stress, which contribute to the occurrences of vasoocclusion.

Objectives: To measure hematological parameters and their relationship to the development of vasoocclusion.

Materials and Methods: This case-control study was conducted on 80 Iraqi subjects, including 40 cases with sickle cell disease diagnosed previously by hemoglobin electrophoresis. They were collected from Babylon Teaching Hospital for Maternity and Children when they attended the Hereditary Blood Disease Center in that hospital. Another 40 subject consider as controls. Three milliliters of venous blood were drawn in EDTA tubes, and investigations were made immediately at the laboratory of this Hospital by use of hematology analyzer.

Results: Mean leukocytes in SCD were (10.10 ± 4.70) and (7.53 ± 1.80) for controls, showing a significant difference (P value 0.002). The mean RBC (3.22 ± 0.97), (4.59 ± 0.58) for patients and control respectively. Mean platelets count was (358.68 ± 135.82), (286.52 ± 72.95) for patient and control respectively. The mean PCV (26.48 ± 5.71) for patients and (37.48 ± 5.72) for controls.

Conclusions: There were significant alterations in RBC, WBC, and platelets between SCD patients and controls. Hematocrit and hemoglobin were lower in patients than in controls, and even lower during crises than in steady states.

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