Potential Anti-Parkinsonian Activity of Gastrodia Elata: The Principle of Antioxidant Qualities in a Rat Model

Authors

Marwa S. Mahdy, Department of Pharmacology and Toxicology, College of Medicine, University of Babylon, Hilla, IraqFollow
Reyadh H. AL-Mosawi, Department of Pharmacology and Toxicology, College of Medicine, University of Babylon, Hilla, IraqFollow
Samir S. Hammoud, Department of Physiology and Medical Physics, College of Medicine, University of Babylon, Hilla, IraqFollow

Document Type

>Short Communication

Keywords

Open-field, Malondialdehyde, Lewy bodies, Gastrodia Elata, Rearing, Grooming

Abstract

Background: Parkinson’s disease is a progressive, incurable, and the second most common neurological disorder resulting in the localized destruction of dopaminergic neurons in the pars compacta (PC) of the midbrain.

Objectives: Our study aimed to examine the antioxidant effect of Gastrodia elata on brain tissues of PD animal models depending on results obtained from previous investigations.

Materials and Methods: 40 Wistar adult male rats weighing 200-300mg were placed into 5 separate groups at random, with 8 rats in each group. The course of the study was a 21-day behavioral test carried out on day 21 using an open-field device. Decapitation of rats’ brains was performed on day 22, 24 hours after the last exposure to ROT, and brain tissues were gathered for examination of biochemistry by measuring levels of malondialdehyde (MDA).

Results: A significant reduction in motor action was observed (p-valueConclusion: GE alleviates oxidative damage associated with PD by lowering MDA levels in brain tissues of the PD rat model, so it possesses an antioxidant activity. GE enhances the collaboration of motion in PD rats in the open field apparatus. When used with L-dopa GE has a cumulative effect.

How to Cite This Article

Mahdy, Marwa S.; AL-Mosawi, Reyadh H.; and Hammoud, Samir S. (2024) "Potential Anti-Parkinsonian Activity of Gastrodia Elata: The Principle of Antioxidant Qualities in a Rat Model," Hilla University College Journal For Medical Science: Vol. 2: Iss. 2, Article 10.
DOI: https://doi.org/10.62445/2958-4515.1023