Potential Antidiabetic Activity of Ficus Carica: The Concept of Antioxidant Properties in a Rat Model

Authors

Hawraa Abdul-Jabbar I. Shwayekh, Department of Pharmacology and Toxicology, College of Medicine, University of Babylon, Hill, IraqFollow
Reyadh H. AL-Mosawi, Department of Pharmacology and Toxicology, College of Medicine, University of Babylon, Hill, IraqFollow
Alaa Jafear Mahrath, Department of Biochemistry, College of Medicine, University of Babylon, Hilla, IraqFollow

Document Type

>Short Communication

Keywords

Dibetes mellitus, Ficus carica, Oxidative stress, Obesity, Histopathology, MDA, Redox

Abstract

Background: The benefits associated with a healthy diet can be attributed to higher concentrations of antioxidants found in fruits and vegetables such as flavonoid-polyphenolic compounds, tocopherols, and carotenoids.

Objectives: The aim of the study was to investigate the antioxidant activity of Ficus Carica and the histopathological study in striptozotocin (STZ) induced T2DM in rats and compare the effect of the plant with sitagliptin.

Materials and Methods: Forty apparently healthy male Wister rats weighing between 180 and 250 grams were used in the current investigation, which began in December 2023. To create type 2 diabetes mellitus (T2 DM), rats were fed a high-fat diet (HDF) for two weeks before being injected intraperitoneal (STZ). Wistar rats were randomly divided into five groups, each group including eight rats. Group 1 animals received only normal saline. Group 2 animals received IP streptozotocin (STZ) 35 mg /kg and were left without any treatment.Group 3 animals received IP STZ 35mg /kg and sitagliptin 10 mg /kg. Group 4 animals received IP STZ 35mg/kg and Ficus Carica extract 200mg /kg. Group 5 animals received IP STZ 35mg/kg and sitagliptin 10mg /kg and Ficua Carica extract 200mg /kg. At the end of the study the animals were sacrificed, and collection of blood sample for the estimation of MDA and liver histopathological study.

Results: Treatment with Ficus Carica showed a highly significant (p

Conclusion: Ficua Carica possesses antioxidant properties by the effect on lipid peroxidation (MDA) in STZ induced T2DM at a dose 200mg/kg and has liver protective activity. Additionally, sitagliptin exhibited antioxidant and anti-inflammatory activity at a dose 10 mg/kg. in diabetic male rats.

How to Cite This Article

Shwayekh, Hawraa Abdul-Jabbar I.; AL-Mosawi, Reyadh H.; and Mahrath, Alaa Jafear (2024) "Potential Antidiabetic Activity of Ficus Carica: The Concept of Antioxidant Properties in a Rat Model," Hilla University College Journal For Medical Science: Vol. 2: Iss. 2, Article 11.
DOI: https://doi.org/10.62445/2958-4515.1024