•  
  •  
 

Hilla University College Journal For Medical Science

Document Type

Original Study

Keywords

PCOS, Vaginitis, Human Pentraxin 3

Abstract

Background: Polycystic ovary syndrome (PCOS) is a chronic reproductive and metabolic disorder that affects up to 20% of women in their reproductive age, leading to menstrual complications, fertility problems, and other health issues. Vaginitis is a clinical disorder that can result in vaginal symptoms.

Objectives: to compare the vaginal and plasma pentraxin-3 levels among females with polycystic ovary syndrome.

Materials and Methods: Vaginal swabs and venous blood were collected during the present study period, extending from the beginning of August to the end of November 2023, from female patients who were attended to Babylon Maternity and Pediatrics Hospital and Private Clinics, the samples were collected from females with vaginitis and PCOS, and 74 females with vaginitis without PCOS as the control group. High vaginal swabs were collected and processed by culture media followed by identification depending on microscopic, phenotypic, cultivation on Chromagar and application of Human Pentraxin 3 ELISA on both vaginal swabs and blood samples.

Results: A total of (164) females were diagnosed as having polycystic ovary syndrome depending on Rotterdam criteria. The results revealed that 60/164 (36.59%) had positive cultures; these 60 cultures were divided into 22/164 (13.4%) bacterial isolates and the remaining 38/164 (23.2%) had fungal isolates. The results of Pentraxin 3 showed that blood levels were significantly different between patients and controls, also the same for vaginal pentraxin with p value < 0.05. While no correlation between blood and vaginal levels.

Conclusion: Plasma and vaginal Pentraxin 3 levels were significantly elevated and associated with PCOS, giving a hint for further studying the role of pentraxin in the pathophysiology of PCOS.

Download

Share

COinS