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Hilla University College Journal For Medical Science

Document Type

Original Study

Keywords

Anticancer activity, Silver Oxide Nanoparticles, Terephthalic acid

Abstract

Silver oxide nanoparticles (Ag2O NPs) synthesized using terephthalic acid have demonstrated significant potential as anti-cancer agents. This study aimed to synthesize these nanoparticles using an eco-friendly chemical reduction method and evaluate their anti-cancer efficacy against HepG2 liver cancer cells. The nanoparticles were characterized by Dynamic Light Scattering (DLS), Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction (XRD), and Fourier-Transform Infrared Spectroscopy (FTIR). The characterization confirmed their spherical morphology, uniform size distribution, and well-defined crystalline structure, with an average particle diameter of approximately 75 nm. The anti-cancer potential of the synthesized nanoparticles was assessed through in vitro cytotoxicity and apoptosis assays. The MTT assay revealed a dose-dependent reduction in cell viability, with an IC50 value of 50 µg/mL, indicating that the nanoparticles were effective in inhibiting cancer cell proliferation. Furthermore, acridine orange/propidium iodide (AO/PI) staining demonstrated that approximately 65% of the treated cells underwent apoptosis, confirming the pro-apoptotic efficacy of the nanoparticles.

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