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Hilla University College Journal For Medical Science

Corresponding Author

Hayder Jasim Taher

Document Type

Review

Keywords

Intravoxel incoherent motion, Diffusion-weighted imaging, Acute stroke

Abstract

Background and objective: Intravoxel incoherent motion (IVIM) has the potential to provide both diffusion and perfusion information without an exogenous contrast agent, its application for the brain is promising, however, feasibility studies on this are relatively scarce. The present study aims to assess the evaluate the feasibility of using intravoxel incoherent motion (IVIM) to measure diffusion parameter variations in stroke.

Methods: To this end, we searched international databases (Web of Science, PubMed, Embase, and Scopus) and extracted related studies using the appropriate keywords. Collected data were analyzed with the aid of the random-effects model and STATA (version 15).

Results: A total of eight studies met the eligibility criteria, and the total sample size was 293 subjects. The mean age was 65.68 ± 13.68 years. The results showed a significant decrease between the ischemic core compared with the contralateral normal region for f value in stroke patients (SMD=-1.38, 95% CI -2.07 to -0.68, P < 0.001). Also, there was a significant decrease between the ischemic core compared with the contralateral normal region for D value in stroke patients (SMD = -3.14, 95% CI -3.38 to -2.89, P < 0.001). The D* parameter of the IVIM significantly decreases in the ischemic core compared with the contralateral normal region in stroke patients (SMD = -0.33, 95% CI -0.50 to 0.16, p = 0.09). Also, the results showed that the fD* parameter and ADC of the IVIM significantly decrease in the ischemic core compared with the contralateral normal region of stroke patients (SMD = -0.86, 95% CI -2.15 to 0.43, p < 0.01), and (SMD = -2.04, 95% CI -3.76 to -0.31, p < 0.01), respectively.

Conclusion: Our findings highlight the promising role of IVIM-DWI in offering quantitative insights into the pathophysiological alterations associated with acute stroke. By revealing significant reductions in diffusion parameters, particularly in perfusion fraction (f) and diffusion coefficient (D) values within ischemic regions compared to healthy tissue.

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