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Hilla University College Journal For Medical Science

Corresponding Author

Buthaina H. Hammadi

Document Type

Original Study

Keywords

Combined oral contraceptives, Factor VII, Estrogen, Progesterone

Abstract

Background: Combined hormonal pills that are used for contraception are widely used around the world as a straightforward, secure, and reversible approach to contraception. Over time, many side effects of these contraceptive pills have been discovered, including prothrombotic effects, one of which is the effect on clotting factor VII.

Objectives: To evaluate the impact of combined hormonal contraceptives on FVII active state percentage and, consequently, the prothrombotic risk associated with these medications.

Materials and Methods: It is a case-control study involving 50 users of COC of different types and compared with other 50 non-user controls after obtaining their verbal consent. The study was conducted at Al-Zahraa Teaching Hospital in Al-Najaf. The tests were conducted in the laboratories of Babylon Medical College using the FVII and performed by the manual method.

Results: The study and control groups’ ages were in the range of (18-45) years. the second generation, which is a combination of levonorgestrel/ethinyl estradiol, is the most commonly used type with 56% percent. The second one is the third generation, which is a combination of gestodene/ethinyl estradiol with 32% and the third one is the fourth generation, which is the combination of drospirenone/ethinyl estradiol with 12%.

Conclusion: Combined oral contraceptive pills increase FVII activity significantly more than users, and this increment was highest in third-generation contraceptives.

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