The Function of Di-Methyl Fumarate in Immunobiochemical and Hematological Changes in Individuals Infected with Entamoeba histolytica

Authors

Saif Mohammed Algebory, Department of Medical Laboratory Technology, College of Health and Medical Technology, University of Gezira, Khartoum, SudanFollow
Zainab Ali Hussein, Department of Medical Laboratory Technology, College of Health and Medical Technology, Al bath University, Damascus, SyriaFollow
Sarah Suliman Mohammed, College of Radiography and Medical Imaging Sciences, National University- Sudan, Khartoum, SudanFollow
Alaa Ihsan Saymeh, CV Raman Global University, Bhubaneswar, IndiaFollow
Hayder Kareem Algabri, Department of Cybersecurity Engineering Technologies, University of Hilla, Babylon, IraqFollow

Corresponding Author

Saif Mohammed Algebory

Document Type

Original Study

Keywords

Amebiasis, Di-Methyl fumarate, Diarrhea, Inflammatory, Entamoeba histolytica

Abstract

Background: Amebiasis can cause a number of symptoms, from infections that are passed on when someone touches something infected to serious illness.

Objectives: role of DMF on reducing Entamoeba histolytica (E. histolytica) infection.

Materials and Methods: The study involved patients supplying E. histolytica-related symptoms. Diagnoses were confirmed using stool samples, and 10 mL of venous blood was obtained for antioxidant and immunological investigation. Groups: Control (uninfected patients), Normal medication (infected patients on normal medication), and Combination (infected patients getting standard treatment with DMF).

Results: Group 2 and 3 had lower red blood cell and haemoglobin levels than group 1. Group 2 was different from groups 1 and 3 (P < 0.05), which shows that DMF reduces red blood cell and haemoglobin loss. Group 1 had higher levels of different types of white blood cells, including neutrophils, monocytes, and eosinophils. Group 1 had lower amounts of lymphocytes compared to groups 2 and 3. Statistical analysis showed a significant decrease in SOD, GSH, and CAT levels in patients receiving E. histolytica standard treatment compared to the healthy control group, while malondialdehyde levels increased a lot (P ≤ 0.05) in the same group. Group 3 showed a significant increase (P ≤ 0.05) in SOD, GSH, and CAT levels compared to the standard therapy group, while malondialdehyde levels increased significantly in patients treated with E. histolytica standard therapy plus DMF.

Conclusion: E. histolytica infection has been found to generate leukocytosis, lower antioxidant levels, and boost MDA. It is advised that a potent antioxidant be added to conventional treatment.

How to Cite This Article

Algebory, Saif Mohammed; Hussein, Zainab Ali; Mohammed, Sarah Suliman; Saymeh, Alaa Ihsan; and Algabri, Hayder Kareem (2025) "The Function of Di-Methyl Fumarate in Immunobiochemical and Hematological Changes in Individuals Infected with Entamoeba histolytica," Hilla University College Journal For Medical Science: Vol. 3: Iss. 3, Article 1.
DOI: https://doi.org/10.62445/2958-4515.1065