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Hilla University College Journal For Medical Science

Corresponding Author

Sawen Tahseen Taha

Authors ORCID

Sawen Tahseen Taha: https://orcid.org/0000-0001-7105-6931

Document Type

Original Study

Keywords

Ceruloplasmin, Malondialdehyde, Obesity, Oxidative stress

Abstract

Background: Higher levels of lipid peroxidation are associated with obesity. Malondialdehyde (MDA) is a byproduct of this process and acts as a biomarker. Plasma ceruloplasmin (Cp) is also connected to obesity and is considered a risk factor for cardiovascular disease.

Objectives: This study aimed to measure MDA and CP levels in obese people and compare them with levels in people of normal weight, including both men and women.

Methods: Case and control study was conducted on a total (90) participants, consisting of (45) Normal individuals with BMI <25 Kg/m2, (45) Obese individuals with BMI ≥ 30 Kg/m2 were enrolled in the study. Serum MDA and CP were estimated using the ELISA technique. The present study was carried out from 8th January 2024, to 1st May 2024, at Rizgary Hospital, Cardiac Center, and Cihan University.

Results: Malondialdehyde (MDA) was assessed in both groups. Sensitivity and specificity for MDA were 95.1(0.95) with significance (p < 0.0001), for CP 93.33(0.93) with significance (p < 0.0001), significant increase in median of MDA from 287.0 (p < 0.0001), median CP from 230.1 (p < 0.0001) in obese subjects. A positive Spearman's correlation between MDA and BMI (P < 0.0001) and between CP with BMI (P < 0.0001), indicating that it is an excellent biomarker for diagnosing obesity.

Conclusion: This finding suggests that obesity is an important factor for enhanced MDA oxidative stress and Cp protein, with the highest sensitivity and specificity, in obese individuals. which may be suggested as a marker of obesity.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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