Serum Transforming Growth Factor-Beta (TGF-β ) as Diagnostic Biomarker for Ulcerative Colitis: An Association Study With ABO Blood Group and Extra Intestinal Symptoms

Authors

• Safaa Muhsin Khudheir, Dept. of Medical Microbiology, College of Medicine, University of Kufa, Najaf, IraqFollow
• Thekra Abdullah Mahmoud, Dept. of Medical Microbiology, College of Medicine, University of Kufa, Najaf, IraqFollow

Corresponding Author

Safaa Muhsin Khudheir

Authors ORCID

Safaa Muhsin Khudheir: https://orcid.org/0009-0005-6277-4495

Thekra Abdullah Mahmoud: https://orcid.org/0000-0001-9037-6738

Document Type

Original Study

Keywords

Ulcerative colitis, Transforming growth factor-beta, Extra intestinal manifestation

Abstract

Background: Ulcerative colitis (UC) is a recurrent and remitting inflammatory bowel disease (IBD). Anti-inflammatory cytokines such as transforming growth factor-beta (TGF-β ) are part of the pathophysiology of UC; these cytokines set off a specific immune response. Extra-intestinal manifestations (EIMs) reported occurrence differs from 14% to 47%, and accounts for the majority of related conditions in UC. This study aims to find the correlation of ulcerative colitis with TGF-β , ABO blood group and EIMs.

Objectives: To determine the serum level of TGF-β in both groups by sandwich ELISA, determine blood group by agglutination slide method, identify extra intestinal manifestation in UC patients.

Methods: enzyme linked immune-sorbent assay was used to assessment serum levels of TGF-β in compliance with the manufacturer's instructions. Agglutination slide method used to detect ABO and rhesus (Rh) group.

Results: non-significant difference in apparently healthy individual compared to UC patients regarding to occupation, smoking, blood group and Rh group as P-value for them was >0.05. UC patients exhibited significant lower concentration mean TGF-β (31.57 ± 23.86 pg/ml) compared to control group (42.93 ± 25.35 pg/ml) (P-value = 0.02).

Conclusion: The findings indicate a decreased serum concentration of TGF-β in UC patient compared to seeming healthy individual with no significant link to clinical symptoms or ABO blood group. These results suggest that TGF-β play role in the pathogenesis of UC independent of clinical presentation or blood type.

How to Cite This Article

Khudheir, Safaa Muhsin and Mahmoud, Thekra Abdullah (2026) "Serum Transforming Growth Factor-Beta (TGF-β ) as Diagnostic Biomarker for Ulcerative Colitis: An Association Study With ABO Blood Group and Extra Intestinal Symptoms," Hilla University College Journal For Medical Science: Vol. 4: Iss. 2, Article 3.
DOI: https://doi.org/10.62445/2958-4515.1105

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.