Formulation and Characterization of Poloxamer-Based Mucoadhesive Vaginal In Situ Gelling System of Miconazole Nitrate

Authors

Omar Mohammed Alwan, Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, IraqFollow
Iman Sabah Jafar, Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, IraqFollow

Document Type

Original Study

Keywords

Miconazole nitrate, Poloxamer, Mucoadhesion, Vaginal candidiasis

Abstract

Background: Vaginal candidiasis is the most prevalent illness among women and is mostly caused by Candida albicans, which causes most clinic visits. Objectives: The present study aimed to formulate and improve miconazole nitrate-containing thermosensitive bioadhesive gel for vaginal drug delivery to achieve better therapeutic effectiveness and patient compliance in the management of vaginal candidiasis. Materials and Methods: Miconazole nitrate (MN) was prepared as a (2%) vaginal gel by using 18% poloxamer (PLX) 407, 2% PLX 188 as thermoresponsive polymers, and Carbopol (CP) 934 and CP 940 as bioadhesive polymers. The prepared formulations were assessed for parameters such as gelation temperature, viscosity, bioadhesive strength, spreadability, and in vitro drug release. Results: The gelation temperatures for F1 were found at 35ºC, and the developed formula had optimum viscosity, good bioadhesive strength, respectable spreadability, and (25%) in vitro drug release over 12 hours. Conclusion: The mucoadhesive in situ gels of MN would be an alternative candidate for vaginal candidiasis treatment since they have suitable gel properties and good vaginal retention.

How to Cite This Article

Alwan, Omar Mohammed and Jafar, Iman Sabah (2024) "Formulation and Characterization of Poloxamer-Based Mucoadhesive Vaginal In Situ Gelling System of Miconazole Nitrate," Hilla University College Journal For Medical Science: Vol. 2: Iss. 3, Article 5.
DOI: https://doi.org/10.62445/2958-4515.1029